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EFSA reassesses feed additive ethoxyquin

07 March 2022

It could not conclude on its safety for animals, consumers and the environment

The European Food Safety Authority has reassessed the feed additive ethoxyquin and could not conclude on its safety for certain groups of animals, consumers and the environment.

Ethoxyquin was authorised in the EU as a feed additive for all animal species and categories until 2017, for its antioxidant properties. In addition, it is used to prevent spontaneous combustion of fish meal during transportation by sea.

The presence of p-phenetidine, an impurity which remains in the additive after the manufacturing process and is a possible mutagen (i.e. likely to cause mutations in the genetic material of animals and humans) meant that the experts of EFSA’s Panel on Additives and Products or Substances used in Animal Feed could not rule out risks to animals with a long-life expectancy and those reared for reproduction. By contrast, the additive is considered safe for animals that are reared for meat production such as chicken, pigs, cattle, rabbits and fish.

Because of the lack of data on the presence of p-phenetidine in tissues and food products of animal origin, the experts could not draw a conclusion for consumers either.

The Panel highlighted the need to minimise users’ exposure via inhalation due to the presence of this impurity in the additive.

Experts could not conclude on the safety of ethoxyquin for the terrestrial and the aquatic ecosystems when the additive is used in terrestrial animals. A risk for contamination via the aquatic food chain cannot be excluded, as well as a risk for marine sediment dwelling organisms exposed to ethoxyquin when used in sea-cages.

The European Commission and the Member States, as risk managers, will consider EFSA’s opinion when reviewing the suspension of the authorisation of the additive.



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